Linezolid oral/injection and Rifadin IV
Determining the interaction of Linezolid oral/injection and Rifadin IV and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using rifAMPin together with linezolid can decrease the effects of linezolid. Contact your doctor if your condition worsens. You may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with rifampin may decrease the plasma concentrations of linezolid. The mechanism of interaction is unknown. In eight healthy subjects, coadministration of a single 600 mg intravenous dose each of rifampin and linezolid resulted in reductions of linezolid concentrations by 10%, 20% and 35% at 6 hours, 9 hours and 12 hours postdose, respectively, compared to administration of linezolid alone.
MANAGEMENT: The potential for diminished pharmacologic effects of linezolid should be considered during coadministration with rifampin.
- Egle H, Trittler R, Kummerer K, Lemmen SW "Linezolid and rifampin: Drug interaction contrary to expectations?" Clin Pharmacol Ther 77 (2005): 451-3
Generic Name: linezolid
Brand name: Zyvox
Synonyms: Linezolid (oral/injection), Linezolid
Generic Name: rifampin
Brand name: Rifadin IV, Rifadin, Rimactane
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Linezolid oral/injection-Rifadin IV Intravenous
- Linezolid oral/injection-Rifamate
- Linezolid oral/injection-Rifampin
- Linezolid oral/injection-Rifampin and Isoniazid
- Linezolid oral/injection-Rifampin Capsules
- Linezolid oral/injection-Rifampin Injection
- Rifadin IV-Linezolid Suspension
- Rifadin IV-Linezolid Tablets
- Rifadin IV-Linzess
- Rifadin IV-Lioresal
- Rifadin IV-Lioresal Double Strength
- Rifadin IV-Lioresal Intrathecal