Lioresal Double Strength and Sinemet 10-100
Determining the interaction of Lioresal Double Strength and Sinemet 10-100 and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using levodopa together with baclofen may cause some unpleasant side effects including hallucination, confusion, headache, nausea, vomiting, unsteadiness, and a worsening of parkinsonian symptoms. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration of levodopa and oral baclofen has rarely resulted in hallucinations, mental confusion, headache, nausea, and exacerbation of parkinsonian symptoms. The mechanism is unknown.
MANAGEMENT: If concurrent use cannot be avoided, monitoring for mental status changes and worsening of symptoms is advisable.
- Skausig OB, Korsgaard S "Hallucinations and baclofen." Lancet 1 (1977): 1258
- Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."
- Cerner Multum, Inc. "Australian Product Information." O 0
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: baclofen
Brand name: Gablofen, Lioresal, Lioresal Intrathecal, FIRST Baclofen, Ozobax
Synonyms: Lioresal Double Strength (Oral), Lioresal
Generic Name: carbidopa / levodopa
Brand name: Parcopa, Rytary, Sinemet, Sinemet CR, Duopa
Synonyms: Carbidopa and levodopa, Carbidopa and Levodopa
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Lioresal Double Strength-Sinemet 100/10
- Lioresal Double Strength-Sinemet 100/25
- Lioresal Double Strength-Sinemet 25-100
- Lioresal Double Strength-Sinemet 25-250
- Lioresal Double Strength-Sinemet 250/25
- Lioresal Double Strength-Sinemet CR
- Sinemet 10-100-Lioresal Intrathecal
- Sinemet 10-100-Liothyronine
- Sinemet 10-100-Liothyronine Injection
- Sinemet 10-100-Liothyronine Intravenous
- Sinemet 10-100-Liothyronine Sodium
- Sinemet 10-100-Liothyronine Tablets