Lioresal Intrathecal and Safinamide

• Generic Name: baclofen
• Dosage Forms: Tablets
• Other Brand Names: Gablofen, Lioresal, Lioresal Intrathecal, FIRST Baclofen, Ozobax

Intrathecal baclofen is used to help relax certain muscles in your body. It relieves the spasms, cramping, and tightness of muscles caused by medical problems such as multiple sclerosis, cerebral palsy, or certain injuries to the spine. Intrathecal baclofen does not cure these problems, but it may allow other treatment, such as physical therapy, to be more helpful in improving your condition.

Intrathecal baclofen acts on the central nervous system (CNS) to produce its muscle relaxant effects. Its actions on the CNS may also cause some of the medicine's side effects.

This medicine is delivered by a drug pump directly into the spinal fluid of your back. A doctor will surgically place the pump and monitor the dose of the medication that is delivered by the pump. The dose of intrathecal baclofen will be different for different patients and will depend on the type of muscle tightness that you have.

Intrathecal baclofen is given only by or under the direct supervision of a doctor.

• Generic Name: safinamide
• Dosage Forms: n.a.
• Other Brand Names: Xadago

Safinamide is monoamine oxidase inhibitor type B (MAO-B). safinamide works by allowing a chemical called dopamine (DOE pa meen) to work for longer periods of time in the brain. Low levels of dopamine in the brain are associated with Parkinson's disease.

Safinamide is given with levodopa and carbidopa to treat "wearing-off" episodes (muscle stiffness, loss of muscle control) in people with Parkinson's disease.

Safinamide may also be used for purposes not listed in this medication guide.