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Lipitor and Rifadin IV

Determining the interaction of Lipitor and Rifadin IV and the possibility of their joint administration.

Check result:

Lipitor <> Rifadin IV

Relevance: 11.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

RifAMPin may significantly reduce the blood levels of atorvastatin, which may make the medication less effective in treating your cholesterol. The interaction may be minimized by taking both medications at the same time. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSING INTERVAL: Chronic administration of rifampin may increase or decrease the plasma concentrations of atorvastatin and atorvastatin acid depending on timing of administration. When a single 40 mg dose of atorvastatin was administered simultaneously with rifampin (600 mg once daily for 7 days), atorvastatin peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 2.7-fold and 30%, respectively, due to inhibition of OATP1B1-mediated hepatic uptake by rifampin. When the dose of atorvastatin was administered 17 hours after the last dose of rifampin given for 5 days, Cmax and AUC of atorvastatin acid decreased by 40% and 80%, respectively, due to induction of CYP450 3A4-mediated metabolism by rifampin.

MANAGEMENT: To minimize impact of the interaction, manufacturers recommend that atorvastatin and rifampin doses be administered simultaneously. Monitoring for adequate hypolipidemic effect is advisable.

References

Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
"Product Information. Lipitor (atorvastatin)." Parke-Davis, Morris Plains, NJ.
Cerner Multum, Inc. "Australian Product Information." O 0
Pharmaceutical Society of Australia "APPGuide online. Australian prescription products guide online. Available from: URL: http://www.appco.com.au/appguide/default.asp." ([2006]):
Backman JT, Luurila H, Neuvonen M, Neuvonen PJ "Rifampin markedly decreases and gemfibrozil increases the plasma concentrations of atorvastatin and its metabolites." Clin Pharmacol Ther 78 (2005): 154-67

Lipitor

Generic Name: atorvastatin

Brand name: Lipitor

Synonyms: n.a.

What is Lipitor?

Rifadin IV

Generic Name: rifampin

Brand name: Rifadin IV, Rifadin, Rimactane

Synonyms: n.a.

What is Rifadin IV?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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