Lithium and Phenytoin Sodium
Determining the interaction of Lithium and Phenytoin Sodium and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Several case reports suggest that phenytoin may increase lithium effects without altering serum lithium levels. The mechanism is unknown. Patients who must take both drugs should be monitored for evidence of lithium toxicity. Other hydantoins may interact with lithium in a similar manner.
- Salem RB, Director K, Muniz CE "Ataxia as the primary symptom of lithium toxicity." Drug Intell Clin Pharm 14 (1980): 622-3
- MacCallum WA "Interaction of lithium and phenytoin." Br Med J 280 (1980): 610-1
- Speirs J, Hirsch SR "Severe lithium toxicity with "normal" serum concentrations." Br Med J 1 (1978): 815-6
- Raskin DE "Lithium and phenytoin interaction." J Clin Psychopharmacol 4 (1984): 120
Generic Name: lithium
Brand name: Lithobid, Eskalith, Lithonate, Lithotabs, Eskalith-CR
Synonyms: n.a.
Generic Name: phenytoin
Brand name: Dilantin, Dilantin Infatabs, Phenytek, Phenytoin Sodium, Prompt
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Lithium-Phenytoin Sodium, Prompt injection
- Lithium-Phenytoin Suspension
- Lithium-Philith
- Lithium-Phillips Milk of Magnesia
- Lithium-Phisohex
- Lithium-Phl-Fluoxetine
- Phenytoin Sodium-Lithium Capsules
- Phenytoin Sodium-Lithium Capsules and Tablets
- Phenytoin Sodium-Lithium Carbonate
- Phenytoin Sodium-Lithium Carbonate ER Tablets
- Phenytoin Sodium-Lithium Carbonate Tablets
- Phenytoin Sodium-Lithium Citrate Syrup