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Lithium and Thorazine

Determining the interaction of Lithium and Thorazine and the possibility of their joint administration.

Check result:

Lithium <> Thorazine

Relevance: 05.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using lithium together with chlorproMAZINE may lead to increased side effects. Contact your doctor if you experience extreme drowsiness or dizziness, feeling like you might pass out, tremors, and uncontrolled muscle movements in your eyes, tongue, jaw, or neck. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Lithium and chlorpromazine have been used together in the setting of acute mania. However, concurrent administration of these drugs may induce a number of neurologic and psychiatric effects, even though phenothiazine levels may be decreased during lithium therapy. Mental status changes, extrapyramidal effects, fever, and other symptoms have been reported. The mechanism is unknown. One case has been reported in which severe hypotension was also associated with this combination.

MANAGEMENT: Patients should be closely monitored for toxic effects (e.g., excessive sedation, extrapyramidal effects). It may be necessary to discontinue one or both agents if an interaction is suspected.

References

Stevenson R, Blanshard C, Patterson D "Ventricular fibrillation due to lithium withdrawal: an interaction with chlorpromazine?" Postgrad Med J 65 (1989): 936-8
Prakash R, Kelwala S, Ban TA "Neurotoxicity with combined administration of lithium and a neuroleptic." Compr Psychiatry 23 (1982): 567-71
Yassa R "A case of lithium-chlorpromazine interaction." J Clin Psychiatry 47 (1986): 90-1
Singh SV "Lithium carbonate/fluphenazine decanoate producing irreversible brain damage." Lancet 2 (1982): 278
Byrne A, Zibin T, Chimich W, Hnatko G "Severe hypotension associated with combined lithium and chlorpromazine therapy - a case report and a review." Can J Psychiatry 39 (1994): 294-6
Sachdev PS "Lithium potentiation of neuroleptic-related extrapyramidal side effects." Am J Psychiatry 143 (1986): 942
Rivera-Calimlim L, Kerzner B, Karch FE "Effect of lithium on plasma chlorpromazine levels." Clin Pharmacol Ther 23 (1978): 451-5

Lithium

Generic Name: lithium

Brand name: Lithobid, Eskalith, Lithonate, Lithotabs, Eskalith-CR

Synonyms: n.a.

What is Lithium?

Thorazine

Generic Name: chlorpromazine

Brand name: Thorazine, Ormazine, Thorazine Spansule

Synonyms: Thorazine (Injection)

What is Thorazine?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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