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Lithium Capsules and Tablets and Theo-Dur

Determining the interaction of Lithium Capsules and Tablets and Theo-Dur and the possibility of their joint administration.

Check result:
Lithium Capsules and Tablets <> Theo-Dur
Relevance: 14.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using lithium together with theophylline can decrease the effects of lithium. If you are already taking these medications, you should be monitored for altered theophylline or lithium effects if either medication is stopped. You may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Theophylline may decrease plasma lithium levels by increasing renal elimination of lithium. The magnitude of the decrease may be sufficient to result in loss of therapeutic control. Also, when lithium is added to a stable theophylline regimen, higher initial lithium dosage may be necessary.

MANAGEMENT: The patient should be closely monitored for altered theophylline or lithium effect when either of these drugs is added to or discontinued from a stable regimen.

References
  • Thomsen K, Schou M "Renal lithium excretion in man." Am J Psychol 215 (1968): 823-7
  • Perry PJ, Calloway RA, Cook BL, Smith RE "Theophylline precipitated alterations of lithium clearance." Acta Psychiatr Scand 69 (1984): 528-37
  • Sierles FS, Ossowski MG "Concurrent use of theophylline and lithium in a patient with chronic obstructive lung disease and bipolar disorder." Am J Psychiatry 139 (1982): 117-8
  • Cook BL, Smith RE, Perry PJ, Calloway RA "Theophylline-lithium interaction." J Clin Psychiatry 46 (1985): 278-9
Lithium Capsules and Tablets

Generic Name: lithium

Brand name: Lithobid, Eskalith, Lithonate, Lithotabs, Eskalith-CR

Synonyms: Lithium

Theo-Dur

Generic Name: theophylline

Brand name: Elixophyllin, Theo-24, Respbid, T-Phyl, Aerolate III, Slo-Bid Gyrocaps, Slo-Phyllin, Theobid, Theo-Dur, Theolair, Theovent, Bronkodyl, Theo-X, Theo-Time, Theochron, Slo-Phyllin 125, Theoclear LA-130, Aerolate JR, Theolair-SR, Theoclear LA-260, Quibron-T, Quibron-T/SR, Uniphyl, Uni-Dur, Aerolate SR, Slo-Phyllin 80, Theoclear-80, Theo-Dur Sprinkles, Theosol-80, Asmalix, Aquaphyllin, Truxophyllin, Slo-Phyllin 250, TheoCap

Synonyms: Theo-Dur (Oral)

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle