Lithium Carbonate ER Tablets and Topamax

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Topiramate may increase the blood levels and effects of lithium. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Let your doctor know if you experience drowsiness, dizziness, diarrhea, vomiting, muscle weakness, muscle incoordination, tremor, blurred vision, ringing in the ear, excessive thirst, and/or increased urination, as these may be symptoms of excessive lithium levels. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with topiramate may increase the serum concentrations of lithium. The exact mechanism of interaction is unknown, but may involve reduced lithium elimination due to competition by topiramate for renal excretion and/or sodium depletion secondary to the inhibitory effect of topiramate on carbonic anhydrase. There have been isolated case reports of patients treated with lithium who developed symptoms of toxicity (e.g., impaired concentration, confusion, memory loss, lethargy, tremor, bradycardia, nystagmus) in association with elevated serum lithium levels following the addition or increase in dosage of topiramate. Temporary withdrawal of lithium and dosage reduction upon reinitiation were necessary to maintain therapeutic levels during coadministration with topiramate. In healthy volunteers, topiramate at a dosage of 200 mg/day has been found to exhibit little or no pharmacokinetic interaction with lithium. However, increases of 27% in peak concentration (Cmax) and 26% in systemic exposure (AUC) of lithium have been observed following topiramate dosages of up to 600 mg/day.

MANAGEMENT: Caution is advised if lithium must be used in combination with topiramate. Pharmacologic response and serum lithium levels should be monitored closely and the dosage adjusted accordingly, particularly following initiation, discontinuation or change of dosage of topiramate in patients who are stabilized on their lithium regimen. Patients should be advised to notify their physician if they experience early symptoms of lithium toxicity such as drowsiness, dizziness, diarrhea, vomiting, muscle weakness, ataxia, tremor, blurred vision, tinnitus, excessive thirst, and increased urination.

Lithium Carbonate ER Tablets

Generic Name: lithium

Brand name: Lithobid, Eskalith, Lithonate, Lithotabs, Eskalith-CR

Synonyms: Lithium

What is Lithium Carbonate ER Tablets?

Topamax

Generic Name: topiramate

Brand name: Qudexy XR, Topamax, Topamax Sprinkle, Topiragen, Trokendi XR, Qudexy XR Sprinkle

Synonyms: n.a.

What is Topamax?