Drug search by name

Lithium Carbonate ER Tablets and Zemuron

Determining the interaction of Lithium Carbonate ER Tablets and Zemuron and the possibility of their joint administration.

Check result:

Lithium Carbonate ER Tablets <> Zemuron

Relevance: 09.09.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using rocuronium together with lithium may increase the effects of rocuronium. You should be closely monitored for prolong breathing cessation. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Limited data suggest that lithium may potentiate the pharmacologic effects of neuromuscular blocking agents. The exact mechanism of interaction is unknown. There have been isolated reports of prolonged apnea and delayed recovery from anesthesia in patients treated with lithium who were administered a neuromuscular blocking agent (succinylcholine or pancuronium) during surgery. Additional data have come from animal studies, thus clinical significance of the interaction has not been determined.

MANAGEMENT: Caution is advised if neuromuscular blocking agents are used in patients who have been treated with lithium. Patients should be monitored closely for development of respiratory depression, and life support should be readily available if needed.

References

Hill GE, Wong KC, Hodges MR "Potentiation of succinylcholine neuromuscular blockade by lithium carbonate." Anesthesiology 44 (1976): 439-42
Martin BA, Kramer PM "Clinical significance of the interaction between lithium and a neuromuscular blocker." Am J Psychiatry 139 (1982): 1326-8
Hill GE, Wong KC, Hodges MR "Lithium carbonate and neuromuscular blocking agents." Anesthesiology 46 (1977): 122-6
"Product Information. Eskalith (lithium)." SmithKline Beecham, Philadelphia, PA.
Borden H, Clarke MT, Katz H "The use of pancuronium bromide in patients receiving lithium carbonate." Can Anaesth Soc J 21 (1974): 79-82

Lithium Carbonate ER Tablets

Generic Name: lithium

Brand name: Lithobid, Eskalith, Lithonate, Lithotabs, Eskalith-CR

Synonyms: Lithium

What is Lithium Carbonate ER Tablets?

Zemuron

Generic Name: rocuronium

Brand name: Zemuron

Synonyms: n.a.

What is Zemuron?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions