Lithium Carbonate Tablets and Phenytoin Extended-Release Capsules
Determining the interaction of Lithium Carbonate Tablets and Phenytoin Extended-Release Capsules and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Several case reports suggest that phenytoin may increase lithium effects without altering serum lithium levels. The mechanism is unknown. Patients who must take both drugs should be monitored for evidence of lithium toxicity. Other hydantoins may interact with lithium in a similar manner.
- Salem RB, Director K, Muniz CE "Ataxia as the primary symptom of lithium toxicity." Drug Intell Clin Pharm 14 (1980): 622-3
- MacCallum WA "Interaction of lithium and phenytoin." Br Med J 280 (1980): 610-1
- Speirs J, Hirsch SR "Severe lithium toxicity with "normal" serum concentrations." Br Med J 1 (1978): 815-6
- Raskin DE "Lithium and phenytoin interaction." J Clin Psychopharmacol 4 (1984): 120
Generic Name: lithium
Brand name: Lithobid, Eskalith, Lithonate, Lithotabs, Eskalith-CR
Synonyms: Lithium
Generic Name: phenytoin
Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt
Synonyms: Phenytoin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Lithium Carbonate Tablets-Phenytoin Infatabs
- Lithium Carbonate Tablets-Phenytoin injection
- Lithium Carbonate Tablets-Phenytoin Intravenous
- Lithium Carbonate Tablets-Phenytoin Oral Suspension
- Lithium Carbonate Tablets-Phenytoin Sodium
- Lithium Carbonate Tablets-Phenytoin Sodium, Prompt injection
- Phenytoin Extended-Release Capsules-Lithium Citrate Syrup
- Phenytoin Extended-Release Capsules-Lithium Controlled-Release and Extended-Release Tablets
- Phenytoin Extended-Release Capsules-Lithium ER
- Phenytoin Extended-Release Capsules-Lithium Oral Solution
- Phenytoin Extended-Release Capsules-Lithium Salts
- Phenytoin Extended-Release Capsules-Lithium Syrup and Oral Solution