Lithium Citrate Syrup and Moduretic 5-50
Determining the interaction of Lithium Citrate Syrup and Moduretic 5-50 and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Ask your doctor before using lithium together with aMILoride, this can increase the effects of lithium. Call your doctor at once if you have any early signs of lithium toxicity, such as nausea, vomiting, diarrhea, drowsiness, muscle weakness, tremor, lack of coordination, blurred vision, or ringing in your ears. You may need a dose adjustment or special test if you take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Amiloride may increase serum lithium levels, resulting in a high risk of lithium toxicity. The mechanism is reduced renal clearance of lithium.
MANAGEMENT: Concurrent use of diuretics and lithium should generally be avoided. Extreme caution is recommended if amiloride and lithium must be used together. Lithium levels should be monitored daily and lithium dose reductions may be required. Patients should be advised to notify their physician if they experience drowsiness, dizziness, weakness, ataxia, vomiting, diarrhea, tinnitus,tremor, thirst, blurry vision, or increased urination.
- Vipond AJ, Bakewell S, Telford R, Nicholls AJ "Lithium toxicity." Anaesthesia 51 (1996): 1156-8
- Dorevitch A, Baruch E "Lithium toxicity induced by combined amiloride HCl- hydrochlorothiazide administration." Am J Psychiatry 143 (1986): 257-8
- "Product Information. Eskalith (lithium)." SmithKline Beecham, Philadelphia, PA.
- Macfie AC "Lithium poisoning precipitated by diuretics." Br Med J 1 (1975): 516
- Bennett WM "Drug interactions and consequences of sodium restriction." Am J Clin Nutr 65 (1997): S678-81
- "Product Information. Midamor (amiloride)." Merck & Co, Inc, West Point, PA.
Generic Name: lithium
Brand name: Lithobid, Eskalith, Lithonate, Lithotabs, Eskalith-CR
Synonyms: Lithium
Generic Name: amiloride / hydrochlorothiazide
Brand name: Moduretic 5-50
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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- Moduretic 5-50-Lithium Controlled-Release and Extended-Release Tablets
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- Moduretic 5-50-Lithium Oral Solution
- Moduretic 5-50-Lithium Salts
- Moduretic 5-50-Lithium Syrup and Oral Solution
- Moduretic 5-50-Lithobid