Lomitapide Mesylate and Neratinib

• Generic Name: lomitapide
• Dosage Forms: n.a.
• Other Brand Names: Juxtapid

Adjunct to a low-fat diet and other lipid-lowering treatments, including LDL apheresis where available, to reduce LDL-cholesterol, total cholesterol, apolipoprotein B (apo B), and non-HDL-cholesterol concentrations in the management of homozygous familial hypercholesterolemia (designated an orphan drug by US FDA for use in this condition).

Safety and efficacy not established in patients with hypercholesterolemia who do not have homozygous familial hypercholesterolemia.

Effects on cardiovascular morbidity and mortality not established.

• Generic Name: neratinib
• Dosage Forms: n.a.
• Other Brand Names: Nerlynx

Neratinib is a cancer medicine that interferes with the growth and spread of cancer cells in the body.

Neratinib is used to treat a certain type of early-stage breast cancer. Neratinib is used for this condition only if your tumor tests positive for a protein called human epidermal growth factor receptor 2 (HER2). HER2 protein can speed the growth of cancer cells.

Neratinib is usually given after you have been treated with another medicine called trastuzumab (Herceptin).

Neratinib may also be used for purposes not listed in this medication guide.