Lonsurf and Rucaparib Camsylate
Determining the interaction of Lonsurf and Rucaparib Camsylate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Rucaparib may increase the blood levels and effects of tipiracil. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with rucaparib may increase the plasma concentrations and the risk of adverse effects of drugs that are substrates of Multidrug and Toxin Extrusion (MATE) 1, MATE 2-K, organic cation transporter (OCT) 1, and/or OCT 2. The proposed mechanism, based on in vitro data, is decreased clearance due to rucaparib-mediated inhibition of these transport proteins. Rucaparib appears to be a potent inhibitor of MATE 1 and MATE2-K, a moderate inhibitor of OCT1, and a weak inhibitor of OCT2.
MANAGEMENT: Caution is advised if rucaparib is used concomitantly with drugs that are substrates of MATE 1, MATE 2-K, OCT 1 and/or OCT 2, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring should be considered whenever rucaparib is added to or withdrawn from therapy with these drugs. Patients should be monitored for the development of adverse effects.
- EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring. Available from: URL: http://www.ema.europa.eu/ema/index.jsp?curl=pages/regulation/document_listing/document_listing_000366.jsp&mid=WC0b01ac058067c852" ([2013 - ]):
Generic Name: rucaparib
Brand name: Rubraca
Synonyms: Rucaparib
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Lonsurf-Ruconest
- Lonsurf-Rufinamide
- Lonsurf-Rufinamide Oral Suspension
- Lonsurf-Rufinamide Tablets
- Lonsurf-Rulox
- Lonsurf-Rum-K
- Rucaparib Camsylate-Loperamide
- Rucaparib Camsylate-Loperamide and Simethicone
- Rucaparib Camsylate-Loperamide Capsules and Tablets
- Rucaparib Camsylate-Loperamide Hydrochloride
- Rucaparib Camsylate-Loperamide Oral Solution
- Rucaparib Camsylate-Loperamide Oral Solution and Suspension