Lopinavir and Ritonavir Oral Solution and Retrovir (Zidovudine Syrup)
Determining the interaction of Lopinavir and Ritonavir Oral Solution and Retrovir (Zidovudine Syrup) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration of ritonavir (300 mg every six hours) has been reported to decrease the area under the plasma concentration-time curve of zidovudine (200 mg every eight hours) by 25%. The plasma level of ritonavir has been reported not to have been affected. The mechanism of this interaction may be related to the induction of hepatic glucuronosyltransferase activities by ritonavir, which may enhance the glucuronidation of zidovudine. Adjustments in zidovudine dosage are unlikely to be necessary.
- "Product Information. Norvir (ritonavir)." Abbott Pharmaceutical, Abbott Park, IL.
Generic Name: lopinavir / ritonavir
Brand name: Kaletra
Synonyms: Lopinavir and ritonavir, Lopinavir and Ritonavir
Generic Name: zidovudine
Brand name: Retrovir
Synonyms: Retrovir (oral/injection), Retrovir
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Lopinavir and Ritonavir Oral Solution-Retrovir Infusion
- Lopinavir and Ritonavir Oral Solution-Retrovir Intravenous
- Lopinavir and Ritonavir Oral Solution-Retrovir oral/injection
- Lopinavir and Ritonavir Oral Solution-Revatio
- Lopinavir and Ritonavir Oral Solution-Revatio Injection
- Lopinavir and Ritonavir Oral Solution-Revatio Intravenous
- Retrovir (Zidovudine Syrup)-Lopinavir and Ritonavir Solution
- Retrovir (Zidovudine Syrup)-Lopinavir and Ritonavir Tablets
- Retrovir (Zidovudine Syrup)-Lopreeza
- Retrovir (Zidovudine Syrup)-Lopressor
- Retrovir (Zidovudine Syrup)-Lopressor (Metoprolol Injection)
- Retrovir (Zidovudine Syrup)-Lopressor (Metoprolol Tablets)