Lopinavir and Ritonavir Solution and Vismodegib
Determining the interaction of Lopinavir and Ritonavir Solution and Vismodegib and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Ritonavir may increase the blood levels and effects of vismodegib. This may increase the risk and/or severity of side effects such as muscle spasm, hair loss, taste disturbances, weight loss, fatigue, nausea, vomiting, diarrhea, decreased appetite, constipation, and joint pain. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with inhibitors of P-glycoprotein may increase the plasma concentrations of vismodegib, which has been shown in vitro to be a substrate of the efflux transporter. The potential for increased pharmacologic effects of vismodegib, including adverse effects such as muscle spasm, alopecia, dysgeusia/ageusia, weight loss, fatigue, nausea, vomiting, diarrhea, decreased appetite, constipation and arthralgia, should be considered.
MANAGEMENT: Caution is advised if vismodegib is used in combination with P-glycoprotein inhibitors.
- "Product Information. Erivedge (vismodegib)." Genentech, South San Francisco, CA.
- Cerner Multum, Inc. "Canadian Product Information." O 0 (2015):
Generic Name: lopinavir / ritonavir
Brand name: Kaletra
Synonyms: Lopinavir and ritonavir, Lopinavir and Ritonavir
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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