Lopinavir and Ritonavir Solution and Zyprexa Intramuscular

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using ritonavir together with OLANZapine may decrease the effects of OLANZapine. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with ritonavir may significantly decrease the plasma concentrations of olanzapine. The mechanism is ritonavir induction of CYP450 1A2 and uridine 5' diphosphate glucuronosyltransferase, the enzymes responsible for the metabolic clearance of olanzapine. In 14 healthy, nonsmoking volunteers, ritonavir (300 mg titrated to 500 mg orally twice a day over 11 days) decreased the mean peak plasma concentration (Cmax), area under the concentration-time curve (AUC) and half-life of olanzapine (10 mg single oral dose) by 40%, 53% and 50%, respectively, compared to administration of olanzapine alone. Oral clearance increased by 115%. All but one subject reported less sedation with olanzapine after ritonavir administration than before.

MANAGEMENT: Patients treated concomitantly with ritonavir may require a higher dosage of olanzapine to control psychotic symptoms. Pharmacologic response to olanzapine should be monitored more closely whenever ritonavir is added to or withdrawn from therapy in patients stabilized on their antipsychotic regimen, and the olanzapine dosage adjusted as necessary.

Lopinavir and Ritonavir Solution

Generic Name: lopinavir / ritonavir

Brand name: Kaletra

Synonyms: Lopinavir and ritonavir, Lopinavir and Ritonavir

What is Lopinavir and Ritonavir Solution?

Zyprexa Intramuscular

Generic Name: olanzapine

Brand name: Zyprexa Intramuscular, Zyprexa, Zyprexa Zydis, Zyprexa Relprevv

Synonyms: n.a.

What is Zyprexa Intramuscular?