Lopressor Injection and Plaquenil

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Hydroxychloroquine may increase serum levels of metoprolol. The proposed mechanism is inhibition of CYP450 2D6 hepatic metabolism by hydroxychloroquine. In a randomized, double-blind, crossover study, seven healthy subjects with CYP450 2D6 extensive metabolizer phenotypes took 400 mg hydroxychloroquine or placebo twice daily for 8 days, and 100 mg metoprolol orally on the ninth day. Average metoprolol AUC increased by 65% and maximum plasma concentrations increased by 72%. No adverse effects were reported and the clinical significance is unknown. Clinicians should be aware of the possibility of an interaction if adverse beta-blocker effects occur.

Lopressor Injection

Generic Name: metoprolol

Brand name: Lopressor, Kapspargo Sprinkle, Toprol-XL, Toprol XL

Synonyms: Lopressor (Injection), Lopressor

What is Lopressor Injection?

Plaquenil

Generic Name: hydroxychloroquine

Brand name: Plaquenil, Quineprox

Synonyms: n.a.

What is Plaquenil?