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Lopressor (Metoprolol Injection) and Sulfinpyrazone

Determining the interaction of Lopressor (Metoprolol Injection) and Sulfinpyrazone and the possibility of their joint administration.

Check result:

Lopressor (Metoprolol Injection) <> Sulfinpyrazone

Relevance: 10.08.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Sulfinpyrazone may reduce the antihypertensive effect of beta-blockers. The mechanism may be related to induction of beta-blocker metabolism or inhibition of prostaglandin synthesis by sulfinpyrazone. Data are available for oxprenolol only. Close observation for altered beta-blocker effects is recommended if coadministration is necessary.

References

Ferrara LA, Mancini M, Marotta T, Pasanisi F, Fasano ML "Interference by sulphinpyrazone with the antihypertensive effects of oxprenolol." Eur J Clin Pharmacol 29 (1986): 717-9

Lopressor (Metoprolol Injection)

Generic Name: metoprolol

Brand name: Lopressor, Kapspargo Sprinkle, Toprol-XL, Toprol XL

Synonyms: Lopressor (Injection), Lopressor

What is Lopressor (Metoprolol Injection)?

Sulfinpyrazone

Generic Name: sulfinpyrazone

Brand name:

Synonyms: Sulfinpyrazone (Oral)

What is Sulfinpyrazone?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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