Lopressor (Metoprolol Tablets) and Zolmitriptan Orally Disintegrating Tablets
Determining the interaction of Lopressor (Metoprolol Tablets) and Zolmitriptan Orally Disintegrating Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:After one week of dosing with zolmitriptan and propranolol 160 mg/day, the Cmax and AUC of zolmitriptan increased 1.5 times while the Cmax and AUC of the N-desmethyl metabolite decreased by 30% and 15%, respectively. The mechanism of the interaction has not been described. No effects on blood pressure or pulse rate were noted. It does not appear that any special precautions are necessary when coadministering zolmitriptan with beta-blockers, although further post-marketing studies will help to define this interaction.
- "Product Information. Zomig (zolmitriptan)." Zeneca Pharmaceuticals, Wilmington, DE.
Generic Name: metoprolol
Brand name: Lopressor, Kapspargo Sprinkle, Toprol-XL, Toprol XL
Synonyms: Lopressor (Injection), Lopressor
Generic Name: zolmitriptan
Brand name: Zomig, Zomig-ZMT
Synonyms: Zolmitriptan, ZOLMitriptan
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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