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Lorazepam Intensol and Ogestrel 0.5/50

Determining the interaction of Lorazepam Intensol and Ogestrel 0.5/50 and the possibility of their joint administration.

Check result:

Lorazepam Intensol <> Ogestrel 0.5/50

Relevance: 06.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Oral contraceptives may increase the clearance rate of benzodiazepines that undergo glucuronidation (such as lorazepam, oxazepam, and temazepam). Close observation for signs and symptoms of altered benzodiazepine effect is recommended.

References

Scavone JM, Greenblatt DJ, Locniskar A, Shader RI "Alprazolam pharmacokinetics in women on low-dose oral contraceptives." J Clin Pharmacol 28 (1988): 454-7
Billedeau SM, Holder CL, Getek TA "High-performance liquid chromatography of the antihistamine pyrilamine and its N-oxide using electrochemical detection." J Chromatogr 534 (1990): 151-9
Patwardhan RV, Mitchell MC, Johnson RF, Schenker S "Differential effects of oral contraceptive steroids on the metabolism of benzodiazepines." Hepatology 3 (1983): 248-53
Abernethy DR, Greenblatt DJ, Divoll M, Arendt R, Ochs HR, Shader RI "Impairment of diazepam metabolism by low-dose estrogen-containing oral-contraceptive steroids." N Engl J Med 306 (1982): 791-2
Stoehr GP, Kroboth PD, Juhl RP, Wender DB, Phillips JP, Smith RB "Effect of oral contraceptives on triazolam, temazepam, alprazolam, and lorazepam kinetics." Clin Pharmacol Ther 36 (1984): 683-90

Lorazepam Intensol

Generic Name: lorazepam

Brand name: Ativan, Lorazepam Intensol

Synonyms: Lorazepam Intensol (Oral)

What is Lorazepam Intensol?

Ogestrel 0.5/50

Generic Name: ethinyl estradiol / norgestrel

Brand name: Cryselle 28, Low-Ogestrel, Ogestrel-28, Cryselle-28, Elinest, Ogestrel, Lo/Ovral-21, Lo/Ovral-28, Ovral, Ovral-28, Low-Ogestrel-21, Ovral-21

Synonyms: Ogestrel-28

What is Ogestrel 0.5/50?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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