Lorbrena and Neratinib Maleate

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Lorlatinib may significantly reduce the blood levels of neratinib, which may make the medication less effective in treating your cancer. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with potent or moderate inducers of CYP450 3A4 may significantly decrease the plasma concentrations of neratinib, which is primarily metabolized by the isoenzyme. According to the product labeling, when a single 240 mg oral dose of neratinib was administered with the potent CYP450 3A4 inducer rifampin in a study of 24 healthy volunteers, neratinib peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by 76% and 87%, respectively, compared to administration of neratinib alone. The AUC of two major active metabolites of neratinib were also reduced by 37% to 49% in the presence of rifampin. Simulations using physiologically-based pharmacokinetic (PBPK) models indicate that moderate CYP450 3A4 inducers may decrease the Cmax and AUC of neratinib by 12% and 32%, respectively.

MANAGEMENT: Given the potential for reduced efficacy of neratinib, concomitant use with potent or moderate inducers of CYP450 3A4 should generally be avoided. According to some authorities, if the CYP450 3A4 inducer cannot be avoided, the dose of neratinib should be increased to 320 mg once daily. The daily dose of neratinib should not exceed 320 mg. The previous dose of neratinib may be resumed following discontinuation of the CYP450 3A4 inducer.

Lorbrena

Generic Name: lorlatinib

Brand name: Lorbrena

Synonyms: n.a.

What is Lorbrena?

Neratinib Maleate

Generic Name: neratinib

Brand name: Nerlynx

Synonyms: Neratinib

What is Neratinib Maleate?