Lorbrena and Pramipexole Dihydrochloride

• Generic Name: lorlatinib
• Dosage Forms: tablet, film coated
• Other Brand Names: Lorbrena

Lorbrena (lorlatinib) is prescription medicine used to treat a certain type of non-small cell lung cancer that has spread to other parts of the body.

Lorbrena is used only if your cancer has a specific genetic marker (an abnormal "ALK" gene). Your doctor will test you for this gene.

Lorbrena is given after other cancer treatments did not work or have stopped working.

Lorbrena was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, some people responded to this medicine, but further studies are needed.

• Generic Name: pramipexole
• Dosage Forms: n.a.
• Other Brand Names: Mirapex, Mirapex ER

Symptomatic management of idiopathic parkinsonian syndrome.

Used as an adjunct to levodopa for the symptomatic management of parkinsonian syndrome in patients with advanced disease.

Also used as monotherapy for the initial symptomatic management of parkinsonian syndrome. Most clinicians would use levodopa for initial therapy in individuals >70 years of age (less likely than younger individuals to develop levodopa-related motor complications and because of concerns about cognitive dysfunction), in patients with cognitive impairment, and in those with severe disease. A dopamine receptor agonist may be preferred for initial therapy in patients ≤70 years of age.

Symptomatic management of moderate-to-severe primary restless legs syndrome (Ekbom syndrome).