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Lorbrena and Venclexta Starting Pack

Determining the interaction of Lorbrena and Venclexta Starting Pack and the possibility of their joint administration.

Check result:
Lorbrena <> Venclexta Starting Pack
Relevance: 10.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using venetoclax together with lorlatinib is not recommended. Combining these medications may significantly reduce the blood levels of venetoclax, which may make the medication less effective in treating your cancer. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Coadministration with potent and moderate inducers of CYP450 3A4 may significantly decrease the plasma concentrations of venetoclax, which is primarily metabolized by the isoenzyme. In 10 healthy volunteers, venetoclax peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by 42% and 71%, respectively, when coadministered with 600 mg once daily for 13 days of rifampin, a potent CYP450 3A4 inducer. Therapeutic failure may occur.

MANAGEMENT: Concomitant use of venetoclax with potent and moderate CYP450 3A4 inducers should generally be avoided. Alternative agents with no or minimal CYP450 3A4 induction potential are recommended whenever possible.

References
  • "Product Information. Venclexta (venetoclax)." AbbVie US LLC, North Chicago, IL.
Lorbrena

Generic Name: lorlatinib

Brand name: Lorbrena

Synonyms: n.a.

Venclexta Starting Pack

Generic Name: venetoclax

Brand name: Venclexta, Venclexta Starting Pack

Synonyms: Venclexta

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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