Lorcaserin and Metoprolol Extended-Release Capsules
Determining the interaction of Lorcaserin and Metoprolol Extended-Release Capsules and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Lorcaserin may increase the blood levels and effects of metoprolol. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you experience increased side effects or your condition changes. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with lorcaserin may increase the plasma concentrations of drugs that are primarily metabolized by CYP450 2D6. The mechanism is decreased clearance due to inhibition of CYP450 2D6 activity by lorcaserin. In a study consisting of 21 CYP450 2D6 extensive metabolizers, administration of the probe substrate dextromethorphan in combination with lorcaserin 10 mg twice daily for 4 days increased dextromethorphan peak concentrations (Cmax) by approximately 76% and systemic exposure (AUC) by approximately 2-fold.
MANAGEMENT: Caution is advised if lorcaserin is prescribed concomitantly with medications that undergo metabolism by CYP450 2D6, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever lorcaserin is added to or withdrawn from therapy.
- "Product Information. Belviq (lorcaserin)." Eisai Inc, Teaneck, NJ.
Generic Name: lorcaserin
Brand name: Belviq, Belviq XR
Synonyms: n.a.
Generic Name: metoprolol
Brand name: Kapspargo Sprinkle, Lopressor, Toprol-XL, Toprol XL
Synonyms: Metoprolol
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Lorcaserin-Metoprolol Extended-Release Tablets
- Lorcaserin-Metoprolol Injection
- Lorcaserin-Metoprolol Intravenous
- Lorcaserin-Metoprolol Succinate
- Lorcaserin-Metoprolol Succinate ER Capsules
- Lorcaserin-Metoprolol Succinate ER Tablets
- Metoprolol Extended-Release Capsules-Lorcaserin Extended-Release Tablets
- Metoprolol Extended-Release Capsules-Lorcaserin Hydrochloride
- Metoprolol Extended-Release Capsules-Lorcaserin Tablets
- Metoprolol Extended-Release Capsules-Lorcet
- Metoprolol Extended-Release Capsules-Lorcet Plus
- Metoprolol Extended-Release Capsules-Lorcet Tablets