Lorcaserin and Tylenol Maximum Strength Flu Nighttime
Determining the interaction of Lorcaserin and Tylenol Maximum Strength Flu Nighttime and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Lorcaserin may increase the blood levels and effects of diphenhydrAMINE. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you experience increased side effects or your condition changes. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with lorcaserin may increase the plasma concentrations of drugs that are primarily metabolized by CYP450 2D6. The mechanism is decreased clearance due to inhibition of CYP450 2D6 activity by lorcaserin. In a study consisting of 21 CYP450 2D6 extensive metabolizers, administration of the probe substrate dextromethorphan in combination with lorcaserin 10 mg twice daily for 4 days increased dextromethorphan peak concentrations (Cmax) by approximately 76% and systemic exposure (AUC) by approximately 2-fold.
MANAGEMENT: Caution is advised if lorcaserin is prescribed concomitantly with medications that undergo metabolism by CYP450 2D6, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever lorcaserin is added to or withdrawn from therapy.
- "Product Information. Belviq (lorcaserin)." Eisai Inc, Teaneck, NJ.
Generic Name: lorcaserin
Brand name: Belviq, Belviq XR
Synonyms: n.a.
Generic Name: acetaminophen / diphenhydramine / pseudoephedrine
Brand name: Benadryl Allergy/Cold, Tylenol Maximum Strength Flu Nighttime
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Lorcaserin-Tylenol NightTime Cold & Flu
- Lorcaserin-Tylenol PM
- Lorcaserin-Tylenol Severe Allergy
- Lorcaserin-Tylenol Sinus Congestion and Pain
- Lorcaserin-Tylenol Sinus Congestion Nighttime
- Lorcaserin-Tylenol Sinus Congestion/Pain (Acetaminophen and Phenylephrine Tablets)
- Tylenol Maximum Strength Flu Nighttime-Lorcaserin Extended-Release Tablets
- Tylenol Maximum Strength Flu Nighttime-Lorcaserin Hydrochloride
- Tylenol Maximum Strength Flu Nighttime-Lorcaserin Tablets
- Tylenol Maximum Strength Flu Nighttime-Lorcet
- Tylenol Maximum Strength Flu Nighttime-Lorcet Plus
- Tylenol Maximum Strength Flu Nighttime-Lorcet Tablets