Lorlatinib and Mifepristone Tablets (For High Blood Sugar)
Determining the interaction of Lorlatinib and Mifepristone Tablets (For High Blood Sugar) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Lorlatinib may reduce the blood levels and effects of miFEPRIStone. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of mifepristone, which is primarily metabolized by the isoenzyme. However, the interaction has not been studied, and the clinical impact is unknown.
MANAGEMENT: When mifepristone is prescribed daily to control hyperglycemia secondary to hypercortisolism in patients with endogenous Cushing's syndrome, concomitant use with potent CYP450 3A4 inducers such as carbamazepine, phenobarbital, phenytoin, and rifamycins should generally be avoided. Other, less potent inducers such as aminoglutethimide, barbiturates, bexarotene, bosentan, dabrafenib, efavirenz, nafcillin, nevirapine, somatrem, somatropin, and various other anticonvulsants may also interact. Caution is advised if they are used with mifepristone.
- "Product Information. Mifeprex (mifepristone)" Danco Laboratories, New York, NY.
- "Product Information. Korlym (mifepristone)." Corcept Therapeutics Incorporated, Menlo Park, CA.
Generic Name: mifepristone
Brand name: Korlym, Mifeprex
Synonyms: Mifepristone
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Lorlatinib-Migalastat
- Lorlatinib-Migalastat Hydrochloride
- Lorlatinib-Migergot
- Lorlatinib-Migergot Suppository
- Lorlatinib-Miglitol
- Lorlatinib-Miglustat
- Mifepristone Tablets (For High Blood Sugar)-Lortab
- Mifepristone Tablets (For High Blood Sugar)-Lortab (Hydrocodone and Acetaminophen Liquid)
- Mifepristone Tablets (For High Blood Sugar)-Lortab (Hydrocodone and Acetaminophen Tablets and Capsules)
- Mifepristone Tablets (For High Blood Sugar)-Lortab Oral Solution
- Mifepristone Tablets (For High Blood Sugar)-Lortab Tablets
- Mifepristone Tablets (For High Blood Sugar)-Lortuss DM