Lorlatinib and PCE Dispertab

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Erythromycin may increase the blood levels of lorlatinib in some patients. This may increase the risk of serious side effects such as seizures, hallucinations, cognitive problems (e.G., confusion, forgetfulness, difficulty concentrating), mood disorders (e.G., depression), sleep impairment, increases in cholesterol and triglycerides, slow or abnormal heartbeats, and inflammation of the lungs. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. You should contact your doctor if you experience dizziness, lightheadedness, abnormal heartbeats, or any new or worsening lung problems such as difficulty breathing, shortness of breath, cough, or fever. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of lorlatinib, which has been found to be metabolized primarily by CYP450 3A4 and UGT1A4 in vitro. According to the product labeling, administration of a single 100 mg oral dose of lorlatinib with itraconazole, a potent CYP450 3A4 inhibitor, increased lorlatinib peak plasma concentration (Cmax) and systemic exposure (AUC) by 24% and 42%, respectively. Increased exposure to lorlatinib may increase the risk of central nervous system adverse effects (e.g., seizures, hallucinations, changes in cognitive function, mood disorders, mental status changes, sleep impairment), hyperlipidemia (hypercholesterolemia and hypertriglyceridemia), PR interval prolongation and atrioventricular (AV) block, and interstitial lung disease/pneumonitis. The extent to which other, less potent CYP450 3A4 inhibitors may affect lorlatinib is unknown.

MANAGEMENT: Caution is advised when lorlatinib is used with CYP450 3A4 inhibitors. Patients should be monitored for the development of central nervous system and other adverse effects, and the dosing adjusted or discontinued in accordance with the lorlatinib product labeling.

Lorlatinib

Generic Name: lorlatinib

Brand name: Lorbrena

Synonyms: n.a.

What is Lorlatinib?

PCE Dispertab

Generic Name: erythromycin

Brand name: EES. Granules, EES-400 Filmtab, EryPed 200, EryPed 400, Ery-Tab, Erythrocin Lactobionate, Erythrocin Stearate Filmtab, PCE Dispertab, E. E. S, EryPed, Erythrocin, Erythromycin Filmtabs, Erythromycin Lactobionate - IV

Synonyms: PCE Dispertab (Oral), PCE, PCE (Oral)

What is PCE Dispertab?