Losartan and Hydrochlorothiazide and Pentobarbital Sodium
Determining the interaction of Losartan and Hydrochlorothiazide and Pentobarbital Sodium and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Concomitant administration of phenobarbital and losartan has been reported to decrease the area under the plasma concentration-time curve (AUC) of losartan and its active metabolite by as much as 20%. The mechanism is thought to be induction of losartan metabolism by phenobarbital. While data is available for phenobarbital only, theoretically this interaction may occur with other barbiturates. The reduction in the AUC was not considered significant, however, clinical monitoring for evidence of altered losartan effect is recommended if these drugs are used together.
- Goldberg MR, Lo MW, Deutsch PJ, Wilson SE, Mcwilliams EJ, Mccrea JB "Phenobarbital minimally alters plasma concentrations of losartan and its active metabolite e-3174." Clin Pharmacol Ther 59 (1996): 268-74
Generic Name: hydrochlorothiazide / losartan
Brand name: Hyzaar
Synonyms: Hydrochlorothiazide and losartan
Generic Name: pentobarbital
Brand name: Nembutal Sodium, Nembutal
Synonyms: Pentobarbital (injection), PENTobarbital
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Losartan and Hydrochlorothiazide-Pentobarbital Sodium Injection
- Losartan and Hydrochlorothiazide-Pentopak
- Losartan and Hydrochlorothiazide-Pentosan polysulfate sodium
- Losartan and Hydrochlorothiazide-Pentostatin
- Losartan and Hydrochlorothiazide-Pentostatin Intravenous
- Losartan and Hydrochlorothiazide-Pentothal
- Pentobarbital Sodium-Losartan Potassium
- Pentobarbital Sodium-Losartan Potassium and Hydrochlorothiazide
- Pentobarbital Sodium-LoSeasonique
- Pentobarbital Sodium-Losec
- Pentobarbital Sodium-Lotemax
- Pentobarbital Sodium-Lotemax (Loteprednol Eye Drops 0.5% and 1%)