Losartan Potassium and Hydrochlorothiazide and Obeticholic acid

• Generic Name: hydrochlorothiazide / losartan
• Dosage Forms: tablet, film coated
• Other Brand Names: Hyzaar

Hydrochlorothiazide is a diuretic (water pill). Losartan is an angiotensin II receptor antagonist (sometimes called an ARB blocker).

Hydrochlorothiazide and losartan is a combination medicine used to treat high blood pressure (hypertension). It is also used to lower the risk of stroke in certain people with heart disease.

Hydrochlorothiazide and losartan may also be used for purposes not listed in this medication guide.

• Generic Name: obeticholic acid
• Dosage Forms: n.a.
• Other Brand Names: Ocaliva

Primary biliary cholangitis (PBC) is a chronic liver disease that gradually destroys bile ducts in the liver. These ducts deliver bile to the small intestines, to help your body digest fats and nutrients. When PBC destroys these ducts, the bile stays in your liver and damages its cells. This can lead to cirrhosis (scarring of the liver) and liver failure. PBC is a progressive disease that may have no symptoms for many years. Treating PBC can help keep the liver functioning normally.

Obeticholic acid is used to treat PBC in adults and is sometimes used together with another drug called ursodeoxycholic acid (UDCA).

Obeticholic acid was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, some people with PBC responded to obeticholic acid, but further studies are needed.

Obeticholic acid may also be used for purposes not listed in this medication guide.