Losec and Midazolam Injection Hospira
Determining the interaction of Losec and Midazolam Injection Hospira and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Omeprazole may increase the blood levels and effects of midazolam. This can increase the risk of side effects including excessive drowsiness and breathing difficulties. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Omeprazole may increase the pharmacologic effects and serum levels of certain benzodiazepines via hepatic enzyme inhibition. Diazepam and triazolam are the only benzodiazepines that have been specifically studied in this regard.
MANAGEMENT: Patient should be observed for increased sedation. Reduced benzodiazepine dosage may be indicated, especially in the elderly. Benzodiazepines not metabolized via oxidation (i.e., lorazepam, oxazepam, temazepam) are not expected to interact and may be considered as alternatives.
- Gugler R, Jensen JC "Omeprazole inhibits oxidative drug metabolism: studies with diazepam and phenytoin in vivo and 7-ethoxycoumarin in vitro." Gastroenterology 89 (1985): 1235-41
- Andersson T, Cederberg C, Edvardsson G, et al "Effect of omeprazole treatment on diazepam plasma levels in slow versus normal rapid metabolizers of omeprazole." Clin Pharmacol Ther 47 (1990): 79-85
- Caraco Y, Tateishi T, Wood AJJ "Interethnic difference in omeprazole's inhibition of diazepam metabolism." Clin Pharmacol Ther 58 (1995): 62-72
- Shader RI "I recently saw a patient taking omeprazole for a duodenal ulcer who was wobbly and sedated by the small doses of diazepam that he had previously tolerated - how is this explained." J Clin Psychopharmacol 13 (1993): 459
- Andersson T, Andren K, Cederberg C, Edvardsson G, Heggelund A, Lundborg P "Effect of omeprazole and cimetidine on plasma diazepam levels." Eur J Clin Pharmacol 39 (1990): 51-4
Generic Name: omeprazole
Brand name: FIRST Omeprazole, Omeprazole + SyrSpend SF Alka, Prilosec, Prilosec OTC, Zegerid>, Prilosec, Prilosec OTC
Synonyms: Omeprazole
Generic Name: midazolam
Brand name: Versed, Nayzilam
Synonyms: Midazolam
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Losec-Midazolam nasal
- Losec-Midazolam Nasal Spray
- Losec-Midazolam Syrup
- Losec-Midodrine
- Losec-Midodrine Hydrochloride
- Losec-Midol
- Midazolam Injection Hospira-Lotemax
- Midazolam Injection Hospira-Lotemax (Loteprednol Eye Drops 0.5% and 1%)
- Midazolam Injection Hospira-Lotemax (Loteprednol Eye Gel)
- Midazolam Injection Hospira-Lotemax (Loteprednol Eye Ointment)
- Midazolam Injection Hospira-Lotemax Eye Gel
- Midazolam Injection Hospira-Lotemax Eye Ointment