Losec and Theophylline and guaifenesin
Determining the interaction of Losec and Theophylline and guaifenesin and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using theophylline together with omeprazole may increase the effects of theophylline. Contact your doctor if you experience nausea, vomiting, insomnia, tremors, restlessness, uneven heartbeats, and seizure (convulsions). If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Proton pump inhibitors may increase the rate of theophylline absorption from sustained-release formulations. Chronic use of proton pump inhibitors produce sustained hypochlorhydria, which may enhance peristalsis in the small intestine and antiperistalsis in the proximal colon where theophylline is absorbed.
MANAGEMENT: In patients treated with proton pump inhibitors, the possibility of an enhanced pharmacologic response to sustained-release theophylline should be considered. Patients should be closely monitored for development of toxicity, particularly those with theophylline levels in the upper range of normal. Patients should be advised to report any signs of theophylline toxicity including nausea, vomiting, diarrhea, headache, restlessness, insomnia, or irregular heartbeat to their physicians.
- Sommers DK, van Wyk M, Snyman JR, Moncrieff J "The effects of omeprazole-induced hypochlorhydria on absorption of theophylline from a sustained-release formulation." Eur J Clin Pharmacol 43 (1992): 141-3
Generic Name: omeprazole
Brand name: FIRST Omeprazole, Omeprazole + SyrSpend SF Alka, Prilosec, Prilosec OTC, Zegerid>, Prilosec, Prilosec OTC
Synonyms: Omeprazole
Generic Name: guaifenesin / theophylline
Brand name:
Synonyms: Theophylline and guaifenesin (Oral)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Losec-Theophylline Elixir
- Losec-Theophylline in Dextrose
- Losec-Theophylline Injection
- Losec-Theophylline Intravenous
- Losec-Theophylline Liquid
- Losec-Theophylline Oral Solution
- Theophylline and guaifenesin-Lotemax
- Theophylline and guaifenesin-Lotemax (Loteprednol Eye Drops 0.5% and 1%)
- Theophylline and guaifenesin-Lotemax (Loteprednol Eye Gel)
- Theophylline and guaifenesin-Lotemax (Loteprednol Eye Ointment)
- Theophylline and guaifenesin-Lotemax Eye Gel
- Theophylline and guaifenesin-Lotemax Eye Ointment