Lotronex and Luvox

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using fluvoxaMINE and alosetron is not recommended. Taking these drugs together can cause symptoms of constipation or abdomianal cramping. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

CONTRAINDICATED: Coadministration with fluvoxamine may significantly increase the plasma concentrations of alosetron. The proposed mechanism is fluvoxamine inhibition of alosetron metabolism via CYP450 1A2. In 40 healthy female subjects, pretreatment with fluvoxamine (in escalating doses from 50 to 200 mg/day for 16 days) increased the area under the plasma concentration-time curve (AUC) and half-life of alosetron (1 mg single oral dose) by approximately 6-fold and 3-fold, respectively. Fluvoxamine is known to also inhibit CYP450 2C9 and 3A4, both of which have been shown in vitro to be involved in the metabolism of alosetron. However, it is uncertain to what extent inhibition of these isoenzymes actually contribute to the interaction.

MANAGEMENT: Because alosetron is associated with potentially serious and life-threatening, dose-related gastrointestinal adverse effects (e.g., ischemic colitis; intestinal obstruction, perforation, and impaction; toxic megacolon), concomitant use with fluvoxamine is considered contraindicated.

Lotronex

Generic Name: alosetron

Brand name: Lotronex

Synonyms: n.a.

What is Lotronex?

Luvox

Generic Name: fluvoxamine

Brand name: Luvox, Luvox CR

Synonyms: n.a.

What is Luvox?