Luminal and Teriflunomide

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

PHENobarbital may significantly reduce the blood levels of teriflunomide, which may make the medication less effective in treating your condition. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration of teriflunomide with known strong inducers of CYP450 isoenzymes and efflux transporters, such as phenobarbital and St. John's wort, may decrease the plasma concentrations and therapeutic effects of teriflunomide. The proposed mechanism is induction of CYP450 isoenzymes and/or efflux transporters responsible for the metabolic clearance of teriflunomide. Coadministration with repeated doses of rifampin (600 mg once daily for 22 days), a strong inducer of multiple CYP450 isoenzymes and efflux transporters (e.g., CYP450 2B6, 2C8, 2C9, 2C19, 3A4, BCRP, P-gp), resulted in an approximately 40% decrease in teriflunomide (70 mg single dose) exposure.

MANAGEMENT: Caution and close clinical and laboratory monitoring are recommended if teriflunomide is coadministered with strong inducers of CYP450 isoenzymes and/or efflux transporters. Dosage adjustments may be required whenever a strong inducer is added to or withdrawn from therapy.

Luminal

Generic Name: phenobarbital

Brand name: Luminal, Solfoton

Synonyms: n.a.

What is Luminal?

Teriflunomide

Generic Name: teriflunomide

Brand name: Aubagio

Synonyms: n.a.

What is Teriflunomide?