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Lurasidone Hydrochloride and Tegretol

Determining the interaction of Lurasidone Hydrochloride and Tegretol and the possibility of their joint administration.

Check result:
Lurasidone Hydrochloride <> Tegretol
Relevance: 25.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using lurasidone together with carBAMazepine is not recommended. Combining these medications may significantly decrease the blood levels of lurasidone, which can make the medication less effective or ineffective in treating your condition. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

CONTRAINDICATED: Coadministration with potent inducers of CYP450 3A4 may significantly decrease the plasma concentrations of lurasidone, which is primarily metabolized by the isoenzyme. In a pharmacokinetic study, administration of a single 40 mg dose of lurasidone with the potent CYP450 3A4 inducer rifampin (600 mg/day for 8 days) resulted in an 86% decrease in lurasidone peak plasma concentration (Cmax) and an 80% decrease in systemic exposure (AUC) compared to administration alone.

MANAGEMENT: Concomitant use of lurasidone with potent CYP450 3A4 inducers is considered contraindicated.

References
  • "Product Information. Latuda (lurasidone)." Sunovion Pharmaceuticals Inc, Marlborough, MA.
Lurasidone Hydrochloride

Generic Name: lurasidone

Brand name: Latuda

Synonyms: Lurasidone

Tegretol

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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