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Lusedra and Nitrous Oxide

Determining the interaction of Lusedra and Nitrous Oxide and the possibility of their joint administration.

Check result:
Lusedra <> Nitrous Oxide
Relevance: 04.12.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Nitrous oxide may increase the effects of fospropofol. You will be monitored closely by your surgical team during anesthesia, and the doses of each medication adjusted accordingly. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSE: Premedication with morphine (0.15 mg/kg) and nitrous oxide (67% in oxygen) has been shown to decrease maintenance infusion rates of propofol relative to infusion rates required with nonnarcotic premedication (e.g., lorazepam).

MANAGEMENT: If morphine and nitrous oxide are used as premedications, the rate of propofol infusion should be adjusted according to the patient's clinical response.

References
  • Pavlin DJ, Coda B, Shen DD, et al "Effects of combining propofol and alfentanil on ventilation, analgesia, sedation, and emesis in human volunteers." Anesthesiology 84 (1996): 23-37
  • "Product Information. Diprivan (propofol)." Zeneca Pharmaceuticals, Wilmington, DE.
Lusedra

Generic Name: fospropofol

Brand name:

Synonyms: n.a.

Nitrous Oxide

Generic Name: nitrous oxide

Brand name:

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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