Lutetium Lu 177 dotatate and Pyridostigmine Bromide

• Generic Name: lutetium lu 177 dotatate
• Dosage Forms: n.a.
• Other Brand Names: Lutathera

Lutetium Lu 177 dotatate is a radioactive medicine that binds itself to a specific part of certain tumor cells, allowing the radiation to enter and destroy those cells.

Lutetium Lu 177 dotatate is used to treat certain cancers of the digestive tract, including the stomach, pancreas, and intestines.

Lutetium Lu 177 dotatate may also be used for purposes not listed in this medication guide.

• Generic Name: pyridostigmine
• Dosage Forms: n.a.
• Other Brand Names: Mestinon, Mestinon Timespan, Regonol

Symptomatic management of myasthenia gravis to improve muscle strength.

Not effective in patients resistant to anticholinesterase drugs.

Has been used parenterally (IV or IM) for symptomatic treatment of acute exacerbations of myasthenia gravis or when oral therapy was impractical. However, the injectable preparation that was used for this indication no longer is commercially available in the US; the parenteral injection currently commercially available in the US does not include this use in its prescribing information.

Postoperative reversal of the effects of nondepolarizing neuromuscular blocking agents (e.g., gallamine, metocurine, tubocurarine [all no longer commercially available in the US], pancuronium).

Not effective and should not be used for reversal of depolarizing neuromuscular blocking agents (e.g., succinylcholine, decamethonium).

Preexposure prophylaxis against lethal effects of soman nerve agent poisoning in military combat personnel.

Used in conjunction with standard treatment of nerve agent poisoning (i.e., atropine and pralidoxime chloride) and other protective measures (e.g., masks, hoods, overgarments).

Discontinue use at first indication of nerve agent poisoning. Not for use after exposure to soman; not expected to be effective after such exposure and may exacerbate effects of sublethal exposure. (See Military Use for Soman Poisoning Prophylaxis in Boxed Warning.)