Luvox and Ratio-Haloperidol

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using haloperidol together with fluvoxaMINE may increase the effects of haloperidol. Contact your doctor if you experience extreme drowsiness, feeling like you might pass out, tremors, and uncontrolled muscle movements in your eyes, tongue, jaw, or neck. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: The coadministration with fluvoxamine may increase the serum concentrations and pharmacologic effects of haloperidol. The exact mechanism is unknown but may involve fluvoxamine inhibition of CYP450 2D6, 3A4 and/or 1A2, the isoenzymes responsible for the metabolic clearance of haloperidol. In a randomized, crossover study involving four schizophrenic patients stabilized on haloperidol and benztropine, serum haloperidol concentrations increased significantly with increasing dosage and duration of fluvoxamine administration compared to placebo. Combination with fluvoxamine was also associated with significantly impaired performance on tests of delayed recall memory and attentional function. In addition to the pharmacokinetic changes, some investigators have suggested a pharmacodynamic interaction whereby serotonergic agents such as fluvoxamine may have modulating effects on dopaminergic systems, thus augmenting the effect of haloperidol and other neuroleptic agents.

MANAGEMENT: Caution is advised if haloperidol must be administered with fluvoxamine. Patients should be monitored for the development of extrapyramidal symptoms (e.g., tremor, shuffling gait, drooling, mask-like face, tongue stiffness, muscle spasms or rigidity, involuntary movements) and changes in mental status. A lower dosage of haloperidol may be required.

Luvox

Generic Name: fluvoxamine

Brand name: Luvox, Luvox CR

Synonyms: n.a.

What is Luvox?

Ratio-Haloperidol

Generic Name: haloperidol

Brand name: Haldol, Haldol Decanoate

Synonyms: Haloperidol

What is Ratio-Haloperidol?