Luvox CR and Mexitil

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using mexiletine together with fluvoxaMINE may increase the effects of mexiletine. Contact your doctor if you experience nausea, seizures, numbness or tingling, tiredness, dizziness, a loss of consciousness, and a worsening irregular heartbeat. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with fluvoxamine may increase the serum concentrations of mexiletine. The proposed mechanism is decreased clearance of mexiletine due to inhibition of the CYP450 1A2 and possibly 2D6 isoenzymes by fluvoxamine. In a randomized, crossover study consisting of six healthy subjects, fluvoxamine (50 mg orally twice a day for 7 days) increased the peak serum concentration (Cmax) and area under the concentration-time curve (AUC) of a single dose of mexiletine (200 mg) by 16% and 55%, respectively. The oral clearance decreased by 38%.

MANAGEMENT: Caution is advised during concomitant therapy with fluvoxamine and mexiletine. Serum mexiletine levels and electrocardiographic readings should be monitored closely and the dosage adjusted accordingly, particularly following initiation or discontinuation of fluvoxamine in patients who are stabilized on their antiarrhythmic regimen.

Luvox CR

Generic Name: fluvoxamine

Brand name: Luvox CR, Luvox

Synonyms: n.a.

What is Luvox CR?

Mexitil

Generic Name: mexiletine

Brand name: Mexitil

Synonyms: n.a.

What is Mexitil?