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Lysodren and Spironolactone

Determining the interaction of Lysodren and Spironolactone and the possibility of their joint administration.

Check result:

Lysodren <> Spironolactone

Relevance: 12.06.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using spironolactone together with mitotane. Using these medications together can make mitotane less effective. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Some case reports have suggested that spironolactone may inhibit the adrenolytic effects of mitotane.

MANAGEMENT: This combination should be avoided. If these drugs must be used together, the biochemical effects of mitotane should be closely monitored.

References

Wortsman J, Soler NG "Mitotane: spironolactone antagonism in Cushing's syndrome." JAMA 238 (1977): 2527

Lysodren

Generic Name: mitotane

Brand name: Lysodren

Synonyms: n.a.

What is Lysodren?

Spironolactone

Generic Name: spironolactone

Brand name: Aldactone, CaroSpir

Synonyms: n.a.

What is Spironolactone?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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