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Mag 2 Oral, Topical application, Route Not Applicable and Prestalia

Determining the interaction of Mag 2 Oral, Topical application, Route Not Applicable and Prestalia and the possibility of their joint administration.

Check result:

Mag 2 Oral, Topical application, Route Not Applicable <> Prestalia

Relevance: 26.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using magnesium sulfate together with amLODIPine may occasionally cause low blood pressure and temporary muscle paralysis. Let your doctor know if you experience dizziness, lightheadedness, fainting, rapid heartbeat, muscle weakness, poor reflexes, and difficulty moving or breathing. You may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration of intravenous magnesium and nifedipine may result in hypotension and neuromuscular blockade. Several cases have been reported in pregnant patients with preeclampsia. The mechanism is unknown. Other calcium channel blockers may also interact. The risk may be increased in patients with renal impairment.

MANAGEMENT: The cardiovascular, respiratory, and neurologic status of patients should be closely monitored if these drugs must be given concurrently.

References

Waisman GD, Mayorga LM, Camera MI, Vignolo CA, Martinotti A "Magnesium plus nifedipine: potentiation of hypotensive effect in preeclampsia?" Am J Obstet Gynecol 159 (1988): 308-9
Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."
Snyder SW, Cardwell MS "Neuromuscular blockade with magnesium sulfate and nifedipine." Am J Obstet Gynecol 161 (1989): 35-6
"Product Information. Adalat (nifedipine)." Bayer, West Haven, CT.
Benami M, Giladi Y, Shalev E "The combination of magnesium sulphate and nifedipine - a cause of neuromuscular blockade." Br J Obstet Gynaecol 101 (1994): 262-3
Briggs GG, Freeman RK, Yaffe SJ. "Drugs in Pregnancy and Lactation. 9th ed." Philadelphia, PA: Llippincott Williams & Wilkins (2011):
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Mag 2 Oral, Topical application, Route Not Applicable

Generic Name: magnesium sulfate

Brand name: Epsom Salt

Synonyms: Magnesium sulfate, Magnesium Sulfate

What is Mag 2 Oral, Topical application, Route Not Applicable?

Prestalia

Generic Name: amlodipine / perindopril

Brand name: Prestalia

Synonyms: n.a.

What is Prestalia?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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