Magnesium sulfate Oral, Topical application, Route Not Applicable and Nuzyra (Omadacycline Injection)
Determining the interaction of Magnesium sulfate Oral, Topical application, Route Not Applicable and Nuzyra (Omadacycline Injection) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.ADJUST DOSING INTERVAL: Administration of a tetracycline with aluminum, calcium, or magnesium salts significantly decreases tetracycline serum concentrations. The proposed mechanism is chelation of tetracycline by the cation, forming an insoluble complex that is poorly absorbed from the gastrointestinal tract. The interaction has also been reported with parenteral doxycycline and oral antacids. MANAGEMENT: The administration of tetracyclines and preparations containing aluminum, magnesium, or calcium should be separated by two to four hours. References Upton RA "Pharmacokinetic interactions between theophylline and other medication (Part I)." Clin Pharmacokinet 20 (1991): 66-80 Gotz VP, Ryerson GG "Evaluation of tetracycline on theophylline disposition in patients with chronic obstructive airways disease." Drug Intell Clin Pharm 20 (1986): 694-6 "Product Information. Nuzyra (omadacycline)." Paratek Pharmaceuticals, Inc., Boston, MA. Garty M, Hurwitz A "Effect of cimetidine and antacids on gastrointestinal absorption of tetracycline." Clin Pharmacol Ther 28 (1980): 203-7 McCormack JP, Reid SE, Lawson LM "Theophylline toxicity induced by tetracycline." Clin Pharm 9 (1990): 546-9 "Product Information. Seysara (sarecycline)." Allergan Inc, Irvine, CA. Nguyen VX, Nix DE, Gillikin S, Schentag JJ "Effect of oral antacid administration on the pharmacokinetics of intravenous doxycycline." Antimicrob Agents Chemother 33 (1989): 434-6 "Product Information. Declomycin (demeclocycline)." Lederle Laboratories, Wayne, NJ. Deppermann KM, Lode H, Hoffken G, Tschink G, Kalz C, Koeppe P "Influence of ranitidine, pirenzepine, and aluminum magnesium hydroxide on the bioavailability of various antibiotics, including amoxicillin, cephalexin, doxycycline, and amoxicillin-clavulanic acid." Antimicrob Agents Chemother 33 (1989): 1901-7 Covington TR, Lawson LC, Young LL, eds. "Handbook of Nonprescription Drugs. 10th ed." Washington, DC: American Pharmaceutical Association (1993): Neuvonen PJ "Interactions with the absorption of tetracyclines." Drugs 11 (1976): 45-54 D'Arcy PF, McElnay JC "Drug-antacid interactions: assessment of clinical importance." Drug Intell Clin Pharm 21 (1987): 607-17 View all 12 references
Professional:ADJUST DOSING INTERVAL: Administration of a tetracycline with aluminum, calcium, or magnesium salts significantly decreases tetracycline serum concentrations. The proposed mechanism is chelation of tetracycline by the cation, forming an insoluble complex that is poorly absorbed from the gastrointestinal tract. The interaction has also been reported with parenteral doxycycline and oral antacids.
MANAGEMENT: The administration of tetracyclines and preparations containing aluminum, magnesium, or calcium should be separated by two to four hours.
- Upton RA "Pharmacokinetic interactions between theophylline and other medication (Part I)." Clin Pharmacokinet 20 (1991): 66-80
- Gotz VP, Ryerson GG "Evaluation of tetracycline on theophylline disposition in patients with chronic obstructive airways disease." Drug Intell Clin Pharm 20 (1986): 694-6
- "Product Information. Nuzyra (omadacycline)." Paratek Pharmaceuticals, Inc., Boston, MA.
- Garty M, Hurwitz A "Effect of cimetidine and antacids on gastrointestinal absorption of tetracycline." Clin Pharmacol Ther 28 (1980): 203-7
- McCormack JP, Reid SE, Lawson LM "Theophylline toxicity induced by tetracycline." Clin Pharm 9 (1990): 546-9
- "Product Information. Seysara (sarecycline)." Allergan Inc, Irvine, CA.
- Nguyen VX, Nix DE, Gillikin S, Schentag JJ "Effect of oral antacid administration on the pharmacokinetics of intravenous doxycycline." Antimicrob Agents Chemother 33 (1989): 434-6
- "Product Information. Declomycin (demeclocycline)." Lederle Laboratories, Wayne, NJ.
- Deppermann KM, Lode H, Hoffken G, Tschink G, Kalz C, Koeppe P "Influence of ranitidine, pirenzepine, and aluminum magnesium hydroxide on the bioavailability of various antibiotics, including amoxicillin, cephalexin, doxycycline, and amoxicillin-clavulanic acid." Antimicrob Agents Chemother 33 (1989): 1901-7
- Covington TR, Lawson LC, Young LL, eds. "Handbook of Nonprescription Drugs. 10th ed." Washington, DC: American Pharmaceutical Association (1993):
- Neuvonen PJ "Interactions with the absorption of tetracyclines." Drugs 11 (1976): 45-54
- D'Arcy PF, McElnay JC "Drug-antacid interactions: assessment of clinical importance." Drug Intell Clin Pharm 21 (1987): 607-17
Generic Name: magnesium sulfate
Brand name: Epsom Salt
Synonyms: Magnesium sulfate, Magnesium Sulfate
Generic Name: omadacycline
Brand name: Nuzyra
Synonyms: Nuzyra (oral/injection), Nuzyra
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Magnesium sulfate Oral, Topical application, Route Not Applicable-Nuzyra (Omadacycline Tablets)
- Magnesium sulfate Oral, Topical application, Route Not Applicable-Nuzyra Intravenous
- Magnesium sulfate Oral, Topical application, Route Not Applicable-Nuzyra oral/injection
- Magnesium sulfate Oral, Topical application, Route Not Applicable-Ny-Tannic
- Magnesium sulfate Oral, Topical application, Route Not Applicable-Nyaderm
- Magnesium sulfate Oral, Topical application, Route Not Applicable-Nycoff
- Nuzyra (Omadacycline Injection)-Magnesium sulfate, potassium sulfate, and sodium sulfate
- Nuzyra (Omadacycline Injection)-Magnesium Sulfate-Sodium Chloride injection
- Nuzyra (Omadacycline Injection)-Magnesium Water
- Nuzyra (Omadacycline Injection)-Magnesium-Rougier Oral, Topical application, Route Not Applicable
- Nuzyra (Omadacycline Injection)-Magnevist
- Nuzyra (Omadacycline Injection)-Magonate (Magnesium Carbonate)