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Magnesium Water and Pancuronium

Determining the interaction of Magnesium Water and Pancuronium and the possibility of their joint administration.

Check result:
Magnesium Water <> Pancuronium
Relevance: 02.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using magnesium sulfate together with pancuronium may alter the effects of pancuronium. You should be monitored closely for breathing difficulty when these medications are used together. You may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Magnesium salts may enhance the effects of nondepolarizing neuromuscular blocking agents. One study showed a 25% increase in vecuronium potency after intravenous administration of 40 mg/kg of magnesium sulfate.

MANAGEMENT: Patients should be closely monitored for excessive or prolonged neuromuscular blockade and ventilatory support should be immediately available.

References
  • "Product Information. Norcuron (vecuronium)." Organon, West Orange, NJ.
  • Fuchs-Buder T, Wilder-Smith OH, Borgeat A, Tassonyi E "Interaction of magnesium sulphate with vecuronium-induced neuromuscular block." Br J Anaesth 74 (1995): 405-9
Magnesium Water

Generic Name: magnesium sulfate

Brand name: Epsom Salt

Synonyms: Magnesium sulfate, Magnesium Sulfate

Pancuronium

Generic Name: pancuronium

Brand name:

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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