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Magnesium Water and Plazomicin Intravenous

Determining the interaction of Magnesium Water and Plazomicin Intravenous and the possibility of their joint administration.

Check result:

Magnesium Water <> Plazomicin Intravenous

Relevance: 02.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Plazomicin can occasionally cause muscle paralysis, and using it with magnesium sulfate may increase that risk. Although the effect is often self-limiting and not associated with serious injury, respiratory arrest and death can occur when paralysis involves the lung muscles. This is most likely to occur if you are receiving high dosages of either medication or if you have kidney disease. You should be closely monitored by a doctor during treatment. Let your doctor know if you experience muscle weakness and/or breathing difficulties. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR CLOSELY: Aminoglycosides possess neuromuscular blocking activity, which may be additive with that of parenteral magnesium, potentially resulting in severe and/or prolonged respiratory depression during concomitant use. Clinical data are limited; however, this interaction has been reported in animal studies. In addition, aminoglycosides may reduce serum magnesium levels.

MANAGEMENT: Close monitoring for increased or prolonged neuromuscular blockade and respiratory depression is recommended during concomitant use, especially in patients with renal impairment and/or with elevated magnesium levels. It may be advisable to avoid administration of aminoglycosides in infants with hypermagnesemia.

References

Brunton LL, Lazo JS, Parker KL, eds. "Goodman & Gilman's the Pharmacological Basis of Therapeutics. 11th ed." New York, NY: McGraw-Hill (2006):
Watson A, Coffey L, Keogh B, McCann SR "Severe hypomagnesaemia and hypocalcaemia following gentamicin therapy." Isr J Med Sci 76 (1983): 381-3
Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."
Cerner Multum, Inc. "Australian Product Information." O 0
L'Hommedieu CS, Nicholas D, Armes DA, et al "Potentiation of magnesium sulfate-induced neuromuscular weakness by gentamicin, tobramycin, and amikacin." J Pediatr 102 (1983): 629-31

Magnesium Water

Generic Name: magnesium sulfate

Brand name: Epsom Salt

Synonyms: Magnesium sulfate, Magnesium Sulfate

What is Magnesium Water?

Plazomicin Intravenous

Generic Name: plazomicin

Brand name: Zemdri

Synonyms: Plazomicin

What is Plazomicin Intravenous?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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