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Malarone Pediatric and Vivotif

Determining the interaction of Malarone Pediatric and Vivotif and the possibility of their joint administration.

Check result:
Malarone Pediatric <> Vivotif
Relevance: 09.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using typhoid vaccine, live together with proguanil. Proguanil can decrease the effectiveness of typhoid vaccine, live. Medications containing proguanil should not be administered until at least 10 days after the last dose of typhoid vaccine, live. This vaccine works by exposing you to a small dose of the virus or a protein from the virus, which causes the body to develop immunity to the disease. This vaccine will not treat an active infection that has already developed in the body. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without talking to your doctor first.

Professional:

GENERALLY AVOID: The coadministration of proguanil and live attenuated typhoid vaccine has been associated with diminished immunologic response to the vaccine. Proguanil possesses antibacterial activity and may be active against the vaccine strain of Salmonella typhi, thereby preventing a sufficient degree of multiplication to occur in order to induce a protective immune response. Two other antimalarial agents, mefloquine and chloroquine, also possess antibacterial activity but have not been shown to interfere with the immunogenicity of the vaccine.

MANAGEMENT: Medications containing proguanil should not be administered until at least 10 days after the last dose of live attenuated typhoid vaccine.

References
  • "Product Information. Vivotif Berna (typhoid vaccine, live)" Crucell Vaccine Inc, Coral Gables, FL.
Malarone Pediatric

Generic Name: atovaquone / proguanil

Brand name: Malarone, Malarone Pediatric

Synonyms: n.a.

Vivotif

Generic Name: typhoid vaccine, live

Brand name: Vivotif Berna

Synonyms: Typhoid vaccine (live), oral, Typhoid Vaccine

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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Disease interaction