Marcaine HCl and Phenytoin Extended-Release Capsules
Determining the interaction of Marcaine HCl and Phenytoin Extended-Release Capsules and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:One in vitro study has suggested that phenytoin may displace bupivacaine from plasma protein-binding sites. Theoretically, the risk of toxicity from the local anesthetic could increase.
- Ghoneim MM, Pandya H "Plasma protein binding of bupivacaine and its interaction with other drugs in man." Br J Anaesth 46 (1974): 435-8
Generic Name: bupivacaine
Brand name: Marcaine HCl, Marcaine Spinal, Sensorcaine, Sensorcaine-MPF, Sensorcaine-MPF Spinal, Bupivacaine Fisiopharma, Bupivacaine Spinal, Marcaine, Marcaine Preservative Free, P-Care M, ReadySharp Bupivacaine
Synonyms: n.a.
Generic Name: phenytoin
Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt
Synonyms: Phenytoin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Marcaine HCl-Phenytoin Infatabs
- Marcaine HCl-Phenytoin injection
- Marcaine HCl-Phenytoin Intravenous
- Marcaine HCl-Phenytoin Oral Suspension
- Marcaine HCl-Phenytoin Sodium
- Marcaine HCl-Phenytoin Sodium, Prompt injection
- Phenytoin Extended-Release Capsules-Marcaine Preservative Free
- Phenytoin Extended-Release Capsules-Marcaine Spinal
- Phenytoin Extended-Release Capsules-Marcaine/Epinephrine
- Phenytoin Extended-Release Capsules-Marcaine/Epinephrine PF
- Phenytoin Extended-Release Capsules-Mardrops-EX
- Phenytoin Extended-Release Capsules-Margesic