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Mardrops-EX and Pristiq

Determining the interaction of Mardrops-EX and Pristiq and the possibility of their joint administration.

Check result:
Mardrops-EX <> Pristiq
Relevance: 07.09.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Both desvenlafaxine and pseudoephedrine can increase blood pressure and heart rate, and combining them may enhance these effects. Talk to your doctor if you have any questions or concerns, particularly if you have a history of high blood pressure, irregular heart rhythm, or heart disease. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Additive or synergistic effects on blood pressure and heart rate may occur when serotonin-norepinephrine reuptake inhibitors (SNRIs) are combined with sympathomimetic agents such as nasal decongestants, adrenergic bronchodilators, ophthalmic vasoconstrictors, and systemic vasopressors. The use of SNRIs alone has been associated with sustained increases in blood pressure and heart rate, and cases of elevated blood pressure requiring immediate treatment have been reported in postmarketing experience.

MANAGEMENT: Caution is advised if SNRIs are used with other drugs that can increase blood pressure and/or heart rate. Blood pressure and pulse should be measured prior to initiating SNRI therapy and monitored at regular intervals thereafter. Dose reduction or discontinuation of the SNRI should be considered in patients who experience a sustained increase in blood pressure or pulse rate.

References
  • "Product Information. Nucynta (tapentadol)." PriCara Pharmaceuticals, Raritan, NJ.
  • "Product Information. Effexor (venlafaxine)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
  • "Product Information. Pristiq (desvenlafaxine)." Wyeth Laboratories, Philadelphia, PA.
  • "Product Information. Savella (milnacipran)." Forest Pharmaceuticals, St. Louis, MO.
  • "Product Information. Cymbalta (duloxetine)." Lilly, Eli and Company, Indianapolis, IN.
  • "Product Information. Fetzima (levomilnacipran)." Forest Pharmaceuticals, St. Louis, MO.
Mardrops-EX

Generic Name: guaifenesin / pseudoephedrine

Brand name: Mardrops-EX, Triaminic Chest/Nasal, Ambifed-G, Despec-SR, Entex T, Maxifed, Mucinex D, Mucinex D Max Strength, Poly-Vent IR, Respaire-30, Robitussin Severe Congestion, Sinutab Non Drying, Triaminic Softchews Chest Congestion, Tusnel Pediatric Drops, Entex PSE, Zephrex LA, Guaimax-D, Anatuss LA, Touro LA, Medent, Fenex-PSE, Nalex, Syn-Rx, Rymed, Respaire-60 SR, Nasabid, G-Phed, Respaire-120 SR, Guaibid D, Guaifed, Nalex Jr, G-Phed- PD, Sinufed Timecelles, Versacaps, Guaivent PD, Guaibid D Pediatric, Guaifed-PD, Pseudocot-G, Zephrex, Nasatab LA, Eudal SR, Medent LD, Sudal 60/500, Maxifed-G, Tuss-LA, Stamoist E, V-Dec-M, Deconsal LA, D-Feda II, Guaifenex PSE 60, Demibid II, Guiadrine II, Iosal II, Guiatex II, Guiadrine II SR, Defen-LA, Respa-1st, Decongest II, Desal II, Deco-D, GP 500, Guaifed-PSE, Pan-Mist LA, Abletex-PSE, Guiadrine PSE 120, Duratuss, Guai-Vent/PSE, Guaifenex PSE 120, Hi Tex PSE, Guiatex PSE, Guai Sudo, Guaipax PSE, Iotex PSE, Ami-Tex PSE, Pseudo-G/PSI, Zaptec PSE, Ru Tuss DE, Robitussin PE, Guaifenex RX, Guaitab, Biotuss PE, Guiatuss PE, Mastussin PE, Mytussin PE, Q-Tussin PE, Robichem PE, T-Tussin PE, Tusscidin PE, Tussin PE, Sinufed, Venbid TR, Degen II, Pseudoephedrine-GuaiFENesin, Robafen PE, Guaivent, Altarussin PE, S-Pack, Sudafed Non Drying Sinus, Congestac, Uni Tussin PE, Humibid GC, Med-RX, Nasabid SR, Panmist LA, Panmist JR, H 9600 SR, Pseudovent, Pseudovent Ped, Duratuss GP, Aquatab D, Guaifenex GP, Dynex, Profen II, Profen Forte, Durasal II, Miraphen PSE, Guiadrine PSE, Guiatex II SR, We Mist LA, Triaminic Chest Congestion, Coldmist, Aquatab D Dose Pack, Drituss GP, We Mist II LA, Panmist-S, Pseudo GG, Coldmist LA, Coldmist Jr, Sudal SR, Pseudo Max, Pseudovent 400, Levall G, Guaifenex PSE 80, Pseudatex, Touro LA-LD, Guaifenex PSE 85, Poly-Vent, Jr, Nomuc-PE, Ambi 60/580, Ambi 80/780, Ambi 60/1000, Pseudo GG TR, Ru-Tuss Jr, ExeFen, SudaTex-G, Medent-LDI, Ambifed, Tenar PSE, ExeFen-IR, Mucus Relief D

Synonyms: n.a.

Pristiq

Generic Name: desvenlafaxine

Brand name: Khedezla, Pristiq

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle
Disease interaction