Mavyret and Prilosec (Omeprazole Powder for Oral Suspension)

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Omeprazole may reduce the blood levels of glecaprevir in some patients, which may make the medication less effective in treating hepatitis C infection. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with omeprazole may decrease the plasma concentrations of glecaprevir. The mechanism of interaction has not been established. When a single 300 mg-120 mg dose of glecaprevir-pibrentasvir was administered with omeprazole 20 mg once daily to 9 study subjects, glecaprevir peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by 22% and 29%, respectively. When the dose of glecaprevir-pibrentasvir was administered with omeprazole 40 mg once daily (one hour before glecaprevir-pibrentasvir) to 12 study subjects, glecaprevir Cmax decreased by 64% and AUC decreased by 51%. The pharmacokinetics of pibrentasvir were not affected.

MANAGEMENT: According to the manufacturer, no dosage adjustment is necessary for glecaprevir-pibrentasvir during coadministration with omeprazole. However, the potential for diminished pharmacologic effects of glecaprevir-pibrentasvir should be considered during coadministration with higher dosages of omeprazole. Alternative treatments may be required if an interaction is suspected.

Mavyret

Generic Name: glecaprevir / pibrentasvir

Brand name: Mavyret

Synonyms: n.a.

What is Mavyret?

Prilosec (Omeprazole Powder for Oral Suspension)

Generic Name: omeprazole

Brand name: FIRST Omeprazole, Omeprazole + SyrSpend SF Alka, Prilosec, Prilosec OTC, Prilosec, Prilosec OTC, Zegerid>

Synonyms: Prilosec

What is Prilosec (Omeprazole Powder for Oral Suspension)?