Medroxyprogesterone Acetate and Paclitaxel Intravenous

• Generic Name: medroxyprogesterone
• Dosage Forms: n.a.
• Other Brand Names: Provera, Depo-Provera, Depo-subQ provera 104, Depo-Provera Contraceptive

Reduction of the incidence of endometrial hyperplasia and the attendant risk of endometrial carcinoma in postmenopausal women receiving estrogen replacement therapy.

Prevention of pregnancy.

Parenteral medroxyprogesterone: Consider benefits vs risks (e.g., loss of BMD in women of all ages, possible impact on peak bone mass in adolescents, additional impact of pregnancy and/or nursing on BMD). (See Boxed Warning and Effects on Bone under Cautions.)

Management of pain associated with endometriosis. Benefit of therapy for >6 months not established. Consider benefits vs risk of BMD loss in women of all ages and the possible impact on peak bone mass in adolescents. (See Boxed Warning and Effects on Bone under Cautions.)

Treatment of secondary amenorrhea.

Treatment of abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology such as fibroids or uterine cancer.

Adjunctive therapy and palliative treatment of inoperable, recurrent, and metastatic endometrial carcinoma.

Has been used for treatment of metastatic renal cell carcinoma; however, other agents are preferred.

Management of paraphilia (e.g., homosexual, heterosexual, or bisexual pedophilia; heterosexual fetishism, voyeurism, sexual sadism, or exhibitionism; transvestism) in males.

Management of GnRH-dependent (central) forms of precocious puberty; however, GnRH analogs generally are preferred.

Management of GnRH-independent (peripheral) forms of precocious puberty, including familial male precocious puberty (testotoxicosis) and McCune-Albright syndrome.

• Generic Name: paclitaxel
• Dosage Forms: n.a.
• Other Brand Names: Onxol, Taxol

Paclitaxel injection is used to treat advanced cancer of the ovaries, breast, non-small cell lung cancer, and Kaposi sarcoma. Kaposi sarcoma is a cancer of the skin and mucous membranes that is commonly found in patients with acquired immunodeficiency syndrome (AIDS).

Paclitaxel belongs to the group of medicines called antineoplastics. It interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal body cells may also be affected, other unwanted effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects may not be serious but may cause concern. Some effects may not occur until months or years after the medicine is used.

Before you begin treatment with paclitaxel, you and your doctor should talk about the good paclitaxel will do as well as the risks of using it.

Paclitaxel is to be administered only by or under the immediate supervision of your doctor.