Medroxyprogesterone Acetate and Zortress

• Generic Name: medroxyprogesterone
• Dosage Forms: n.a.
• Other Brand Names: Provera, Depo-Provera, Depo-subQ provera 104, Depo-Provera Contraceptive

Reduction of the incidence of endometrial hyperplasia and the attendant risk of endometrial carcinoma in postmenopausal women receiving estrogen replacement therapy.

Prevention of pregnancy.

Parenteral medroxyprogesterone: Consider benefits vs risks (e.g., loss of BMD in women of all ages, possible impact on peak bone mass in adolescents, additional impact of pregnancy and/or nursing on BMD). (See Boxed Warning and Effects on Bone under Cautions.)

Management of pain associated with endometriosis. Benefit of therapy for >6 months not established. Consider benefits vs risk of BMD loss in women of all ages and the possible impact on peak bone mass in adolescents. (See Boxed Warning and Effects on Bone under Cautions.)

Treatment of secondary amenorrhea.

Treatment of abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology such as fibroids or uterine cancer.

Adjunctive therapy and palliative treatment of inoperable, recurrent, and metastatic endometrial carcinoma.

Has been used for treatment of metastatic renal cell carcinoma; however, other agents are preferred.

Management of paraphilia (e.g., homosexual, heterosexual, or bisexual pedophilia; heterosexual fetishism, voyeurism, sexual sadism, or exhibitionism; transvestism) in males.

Management of GnRH-dependent (central) forms of precocious puberty; however, GnRH analogs generally are preferred.

Management of GnRH-independent (peripheral) forms of precocious puberty, including familial male precocious puberty (testotoxicosis) and McCune-Albright syndrome.

• Generic Name: everolimus
• Dosage Forms: tablet
• Other Brand Names: Zortress, Afinitor, Afinitor Disperz

Zortress (everolimus) lowers your body's immune system. The immune system helps your body fight infections. The immune system can also fight or "reject" a transplanted organ such as a liver or kidney. This is because the immune system treats the new organ as an invader.

The Zortress brand of everolimus is used to prevent organ rejection after a kidney or liver transplant. Zortress is used together with cyclosporine, steroids, and other medications.

Afinitor is another brand of everolimus used to treat certain types of cancer. This medication guide provides information only about about Zortress.