Mefloquine Hydrochloride and Norvir (Ritonavir Capsules)
Determining the interaction of Mefloquine Hydrochloride and Norvir (Ritonavir Capsules) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:The coadministration with mefloquine may decrease the steady-state, but not single-dose, plasma concentrations of ritonavir. The mechanism is unknown but may be due to reduction of bile production by mefloquine, which may interfere with the solubility and absorption of ritonavir in the small intestine. In a study consisting of 12 healthy volunteers, mefloquine (250 mg orally once daily for 3 days, then once weekly for 4 weeks) decreased the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of ritonavir (200 mg orally twice daily for 7 days) by 36% and 31%, respectively. The clearance increased by an average of 45% with no change in half-life or plasma protein binding. However, not all subjects had decreased ritonavir concentrations. Also, in a separate phase of the study involving 11 volunteers (8 of whom participated in the first phase), single-dose pharmacokinetics of ritonavir were not altered by mefloquine. Thus, the effects of the interaction, if it exists, may be inconsistent and subject to interpatient variability. Ritonavir had minimal effect on the pharmacokinetics of mefloquine and its carboxylic acid metabolite, despite strong inhibition of CYP450 3A4 activity as demonstated by the erythromycin breath test. Further studies are necessary to confirm or disprove the interaction.
- Khaliq Y, Gallicano K, Tisdale C, Carignan, Cooper C, McCarthy A "Pharmacokinetic interaction between mefloquine and ritonavir in healthy volunteers." Br J Clin Pharmacol 51 (2001): 591-600
Generic Name: mefloquine
Brand name: Lariam
Synonyms: Mefloquine
Generic Name: ritonavir
Brand name: Norvir, Norvir Soft Gelatin
Synonyms: Norvir
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Mefloquine Hydrochloride-Norvir (Ritonavir Oral Solution)
- Mefloquine Hydrochloride-Norvir (Ritonavir Powder Packets)
- Mefloquine Hydrochloride-Norvir (Ritonavir Tablets)
- Mefloquine Hydrochloride-Norvir Tablets
- Mefloquine Hydrochloride-Norwich Aspirin
- Mefloquine Hydrochloride-Nostril
- Norvir (Ritonavir Capsules)-Mefoxin
- Norvir (Ritonavir Capsules)-Mefoxin Premixed
- Norvir (Ritonavir Capsules)-Mega C Acid Plus
- Norvir (Ritonavir Capsules)-Mega Zinc-100
- Norvir (Ritonavir Capsules)-Mega-C
- Norvir (Ritonavir Capsules)-Megace